Human Sera
Cayman Chemical DeltamethrIn 100mg
A type II pyrethroid insecticide and Nav channel modulator; activates Nav1.8 channels and induces a tail current delay in Xenopus oocytes expressing the rat channel at 10 µM; induces mortality in A. sinensis (LC50 = 4.522 ppm) and T. urticae (LC50 = 0.06 g/L); decreases sperm count, motility, and viability and increases the percentage of morphologically abnormal sperm in rats at 5 mg/kg
Cayman Chemical ClozapIn NoxIdehydrochLR 50mg
An MCT1 and MPC inhibitor inhibits lactate update in SiHa human cervix carcinoma cells (IC50 50 nM) inhibits proliferation of SiHa cells in the presence of lactate but not glucose inhibits MPC in isolated tumor cell mitochondria increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model at 3 mg/kg
Cayman Chemical NItIdInchlorIde 100mg
An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection (ED50 = 18.9 mg/kg per day); decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells at 5 µM; decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia; inhibits proliferation of various cancer cells (IC50s = 2.65-370 ng/ml); induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0.1-10 µM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days
Cayman Chemical Lonurus artmsa Lonurn 50mg
An alkaloid that has diverse biological activities; reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction at 15 mg/kg per day; increases hepatic levels of SOD and GSH, reduces serum ALT and AST levels, and inhibits hepatic fibrosis in a diet-induced mouse model of NASH at 200 mg/kg per day; inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 levels in the serum of broiler chicks at 120 mg/kg
Cayman Chemical StearoylLcarnItInchLRId 50mg
A long-chain acylcarnitine; inhibits sodium-dependent [3H]carnitine uptake in HPCT cells by 52% at 500 μM; inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma at 500 μM/ml of plasma; levels are decreased in plasma of patients with chronic fatigue syndrome and increased in patients with end-stage renal disease
Cayman Chemical CefmenoxImehydrochlorIde 100mg
A cephalosporin antibiotic; active against clinical isolates of S. aureus, S. epidermidis, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. marcescens, and E. cloacae in vitro (MICs = 0.013-6.25 μg/ml); active against various Gram-positive and Gram-negative bacterial infections in mice (ED50s = 0.016-66 mg/kg); increases survival in a mouse model of K. pneumoniae infection (SD50 = 7.6 mg/kg); curative in a mouse model of P. mirabilis urinary tract infection (CD50s = 0.4-0.75 mg/kg)
Cayman Chemical BuclIzInhydrochlorIde 50mg
An antihistamine; reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs at 1 mg/kg; induces gross malformations and bone malformations in rats from 40-200 mg/kg; inhibits cancer cell growth by binding to TCTP and inducing cell differentiation
Cayman Chemical 1MyrIstoyl2hydroxysnglyc 100mg
A lysophospholipid; has been used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems
Cayman Chemical TerlIpresInacetate 100mg
A prodrug form of lysipressin; a partial agonist of the vasopressin V1A receptor (Ki = 0.85 µM); an agonist of vasopressin V1B and V2 receptors (Kis = 1.11 and 1.58 µM, respectively); increases MAP and decreases mortality in a rat model of uncontrolled hemorrhagic shock at 15 UG/kg; improves vascular reactivity and increases survival time in a rat model of cecal ligation and puncture-induced septic shock and a rabbit model of LPS-induced septic shock at 2.6 UG/kg per hour in combination with norepinephrine; increases MAP in a rat model of liver cirrhosis
Cayman Chemical IsovalerylLcarnItInchlor 100mg
A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM, respectively
Cayman Chemical -GalocatechIn 100mg
A polyphenol and flavonoid that has diverse biological activities; inhibits adherence of P. gingivalis onto human buccal epithelial cells by >50% at 250 μg/ml; has antimutagenic properties in UV-irradiated E. coli cells; inhibits cell death induced by D-galactosamine and TNF-α in primary cultured mouse hepatocytes by 29.9% at 80 μM; inhibits HCT116 colorectal cancer cell proliferation by 57% at 100 μM
Cayman Chemical ZInc PyrIthIon 100mg
A coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities; active against various bacteria (MICs = 1-4 UG/ml) and the fungus P. ovale at 0.01-10 UG/ml; reduces tumor growth in an SCC-4 mouse xenograft model at 1 mg/kg per week for six weeks; topical application completely prevents Aspergillus growth in soy meal-derived adhesives
