Human Sera
Cayman Chemical Montropen 50mg
A choline salt form of theophylline decreases histamine-induced contractions of isolated guinea pig trachea increases cAMP levels in guinea pig tracheal smooth muscle cells in vitro
Cayman Chemical 4-O-Methylresveratrol 50mg
A sesquiterpene alcohol inhibits the growth of L sulphureus G trabeum L betulina and T versicolor wood decay fungi at 100 g/ml inhibits CYP2B6 and CYP3A4 (Kis 0 9 and 3 4 M respectively) prevents hair follicle dystrophy and reduces hair loss in a mouse model of cyclophosphamide-induced alopecia at 200 mg/kg loaded nanostructured lipid particles reduce compound 48/80-induced peritoneal mast cell degranulation in mice
Cayman Chemical HValProProOHtrIfluoroac 50mg
An inhibitor of Skp2-mediated p27 degradation blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro at 50 M increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells
Cayman Chemical PIrarubIcIn 100mg
A depsidone an inhibitor of PPDK (IC50 42 3 UM) inhibits the growth of C4 but not C3 plants inhibits the growth of the bacteria S aureus and V harveyi (GI50s 8 7 and 69 5 UM respectively) inhibits the growth of H460 MCF-7 and SF-268 cancer cells (GI50s 28 2 50 8 and 44 3 UM respectively)
Cayman Chemical SpIromesIfen 100mg
A photosensitizer active against S. aureus P. aeruginosa E. coli and S. typhimurium when used at 20 UM in combination with PDT induces tumor regression when combined with PDT in several sarcoma rat xenograft models at 5 and 10 mg/kg
Cayman Chemical IsoquercetIn 100mg
A fluorometric probe that acts as a substrate for ALDH1A1 esterase activity and chymotrypsin
Cayman Chemical CefmenoxImehydrochlorIde 100mg
An imidazole antifungal agent completely inhibits growth of a variety of fungi in vitro when used at concentrations of 0.05-30 Ug/ml active against vaginal infections of C. albicans in mice when used vaginally at concentrations of 0.25-2 and 0.1-1 respectively
Cayman Chemical ArtemIsInIc AcId 100mg
An internal standard for the quantification of ethyl-b-D-glucuronide by GC- or LC-MS
Cayman Chemical OrphenadrInhydrochlorIde 50mg
A nucleoside analog inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s 8.5 and 4 M respectively) and multiple human leukemia cell lines (IC50s 1.7-5.8 M) acts synergistically with 5-FU against HT-29 HCT116 PANC-1 and EKVX cancer cells inhibits HSV-1 pyrimidine 2-deoxyribonucleoside kinase (Ki 3.5 M) and reduces HSV-1 viral titer to 0.05 of the control at a concentration of 200 M a DNA adduct formed in response to oxidative stress
Cayman Chemical OlIvetolIc AcId 100mg
An inhibitor of Eg5 (IC50 1.3 UM) inhibits growth (GI50 0.98 UM) induces mitotic arrest (EC50 1.6 UM) and activates caspase-3 (EC50 1.6 UM) in HCT116 cells selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19 retinal pigment epithelial cells reduces tumor growth in an A2780 ovarian cancer mouse xenograft model at 150 mg/kg
Cayman Chemical ZuclopenthIxol 100mg
An W-7 monounsaturated fatty acid increases basal and insulin-stimulated glucose uptake and Glut4 protein levels in 3T3-L1 adipocytes at 200 UM ex vivo increases glucose uptake and aerobic and anaerobic glycolysis and reduces de novo fatty acid synthesis and activity of the lipogenic enzymes ACL and G6PDH in isolated murine adipocytes at 300 mg/kg dietary administration reduces high-fat diet-induced insulin resistance and liver inflammation in mice at 300 mg/kg
Cayman Chemical ntIlImIcInsulfate 50mg
An orally bioavailable inhibitor of STAT3 (32 and 62 inhibition at 10 and 20 UM respectively in MDA-MB-231 cells in a luciferase reporter assay) inhibits proliferation of MCF-7 and MDA-MB-231 breast cancer and AsPC-1 and PANC-1 pancreatic cancer cells (IC50s 0.91 1.64 1.9 and 1.08 UM respectively) inhibits tumor growth in a breast cancer mouse xenograft model at doses of 7.5 mg/kg i.p. or 25 mg/kg p.o. inhibits tumor growth in an orthotopic mouse model of squamous cell carcinoma
Cayman Chemical AcetamIprId 50mg
A selective orally bioavailable inhibitor of JNK1 JNK2 and JNK3 (IC50s 80 90 and 230 nM respectively) induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis
Cayman Chemical -GalocatechIn 100mg
A pan-FGFR inhibitor (IC50s 1.2 2.5 3 and 5.7 nM for FGFR1 -2 -3 and -4 respectively) selective for FGFRs over VEGFR2 (IC50 36.8 nM) inhibits the proliferation of Ba/F3 cells expressing FGFR1 3 or 4 (IC50s 22.1 13.2 and 25 nM respectively) reduces tumor growth in a SNU-16 gastric cancer mouse xenograft model at 10 and 30 mg/kg
Cayman Chemical CItrulInated GRP78R368 Po 1ea
An antiviral agent inhibits influenza A B and C (IC50s 0.013-0.48 Ug/ml) inhibits a GS4071-resistant influenza strain (IC50 0.095 Ug/ml) and RNA viruses (IC50s 4.8-41 Ug/ml) not active against DNA viruses undergoes phosphoribosylation to form T-705-RTP the active form decreases the rate of mortality in influenza-infected mice when used at a dose of 200 mg/kg once daily reduces the lung virus yield in a dose-dependent manner at doses ranging from 50-200 mg/kg per day in influenza-infected mice